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Publication Detail
Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy)
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Breen-Norris JO, Siow B, Walsh C, Hipwell B, Hill I, Roberts T, Hall MG, Lythgoe MF, Ianus A, Alexander DC, Walker-Samuel S
  • Publication date:
  • Journal:
    Magnetic Resonance in Medicine
  • Status:
  • Print ISSN:
© 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine Introduction: To combine numerical simulations, in vitro and in vivo experiments to evaluate the feasibility of measuring diffusion exchange across the cell membrane with diffusion exchange spectroscopy (DEXSY). Methods: DEXSY acquisitions were simulated over a range of permeabilities in nerve tissue and yeast substrates. In vitro measurements were performed in a yeast substrate and in vivo measurements in mouse tumor xenograft models, all at 9.4 T. Results: Diffusion exchange was observed in simulations over a physiologically relevant range of cell permeability values. In vitro and in vivo measures also provided evidence of diffusion exchange, which was quantified with the Diffusion Exchange Index (DEI). Conclusions: Our findings provide preliminary evidence that DEXSY can be used to make in vivo measurements of diffusion exchange and cell membrane permeability.
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