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Publication Detail
Androgen receptor ligands: Agonists and antagonists
  • Publication Type:
    Chapter
  • Authors:
    Orafidiya FA, Monaghan AE, McEwan IJ
  • Publication date:
    01/01/2018
  • Pagination:
    234, 241
  • ISBN-13:
    9780128151457
  • Status:
    Published
  • Book title:
    Encyclopedia of Reproduction
Abstract
© 2018 Elsevier Inc. All rights reserved. The androgen receptor is a key regulator of physiological development in utero and tissue homeostasis in adult men and woman. The activity of the receptor is tightly regulated by the binding of the natural steroid hormone agonists, testosterone and dihydrotestosterone. Activation of the receptor leads to dimerization, nuclear translocation and activation of target genes. Clinically, synthetic agonists are used to treat conditions of hormone insufficiency. Conversely conditions arising from androgen excess or a dependence upon the androgen receptor can be treated with antagonists to blunt the response to natural hormones.
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