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Publication Detail
Antinuclear antibodies, antibodies to DNA, histones, and nucleosomes
  • Publication Type:
  • Authors:
    Isenberg D, Giles I, Hansen JE, Rahman A
  • Publication date:
  • Pagination:
    355, 365
  • ISBN-13:
  • Status:
  • Book title:
    Dubois' Lupus Erythematosus and Related Syndromes
Antinuclear antibodies are present in high titers in over 95% of patients with systemic lupus erythematosus (SLE). The precise targets of these antibodies are, however, highly variable and include double-stranded (ds)DNA, histones, ribonucleoprotein (RNP), and Sm antigens. The presence of antinuclear antibodies (ANAs) is a criterion for SLE but these antibodies are not specific and may be found in healthy individuals (some, but not all, of whom will go on to develop lupus) and those with infections in whom the ANA is a transient phenomenon. Titers of ANA are of little use in reflecting disease activity in SLE.
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