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Publication Detail
Mitochondrial dysfunction and transport in demyelinating disease with inflammation
  • Publication Type:
    Chapter
  • Authors:
    Sajic M
  • Publication date:
    08/06/2016
  • Pagination:
    193, 217
  • ISBN-13:
    9783319286358
  • Status:
    Published
  • Book title:
    Mitochondrial Dysfunction in Neurodegenerative Disorders: Second Edition
Abstract
Demyelinating diseases with inflammation affect both the central and peripheral nervous systems. The histopathological hallmark of these devastating, and sometimes life-threatening, diseases is segmental demyelination of long axonal tracts and varying degrees of inflammation, with important long-term consequences for the function and survival of axons and neurons. Mitochondria are essential for the function of all cells, but maybe more so for neurons, in both physiological and pathological conditions. Healthy neurons utilise a sensitive, responsive and dynamic mitochondrial population for their varied basal metabolism. It is not surprising, then, that mitochondria also play a fundamental role in adaptive mechanisms which enable neurons to survive pathological events such as loss of myelin sheath and exposure to inflammatory mediators. Indeed, it is believed that the survival of axons in such an environment, and perhaps recovery to full functionality, critically depends on the adaptive capacity of its mitochondrial population. This chapter will present and interpret currently available, published knowledge relating to the role of neuronal mitochondria in neuroprotection and neurodegeneration during demyelinating inflammatory diseases of the central and peripheral nervous systems.
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