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Publication Detail
The rec8 gene of Schizosaccharomyces pombe is involved in linear element formation, chromosome pairing and sister-chromatid cohesion during meiosis.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Molnar M, Bähler J, Sipiczki M, Kohli J
  • Publication date:
    09/1995
  • Pagination:
    61, 73
  • Journal:
    Genetics
  • Volume:
    141
  • Issue:
    1
  • Status:
    Published
  • Country:
    United States
  • Print ISSN:
    0016-6731
  • Language:
    eng
  • Keywords:
    Chromatids, Chromosomes, Fungal, Fungal Proteins, Genes, Fungal, Meiosis, Phosphoproteins, Prophase, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Spores, Fungal
Abstract
The fission yeast Schizosaccharomyces pombe does not form tripartite synaptonemal complexes during meiotic prophase, but axial core-like structures (linear elements). To probe the relationship between meiotic recombination and the structure, pairing, and segregation of meiotic chromosomes, we genetically and cytologically characterized the rec8-110 mutant, which is partially deficient in meiotic recombination. The pattern of spore viability indicates that chromosome segregation is affected in the mutant. A detailed segregational analysis in the rec8-110 mutant revealed more spores disomic for chromosome III than in a wild-type strain. Aberrant segregations are caused by precocious segregation of sister chromatids at meiosis I, rather than by nondisjunction as a consequence of lack of crossovers. In situ hybridization further showed that the sister chromatids are separated prematurely during meiotic prophase. Moreover, the mutant forms aberrant linear elements and shows a shortened meiotic prophase. Meiotic chromosome pairing in interstitial and centromeric regions is strongly impaired in rec8-110, whereas the chromosome ends are less deficient in pairing. We propose that the rec8 gene encodes a protein required for linear element formation and that the different phenotypes of rec8-110 reflect direct and indirect consequences of the absence of regular linear elements.
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