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Publication Detail
PDGF mediates a neuron-astrocyte interaction in the developing retina.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Fruttiger M, Calver AR, Kr├╝ger WH, Mudhar HS, Michalovich D, Takakura N, Nishikawa S, Richardson WD
  • Publication date:
  • Pagination:
    1117, 1131
  • Journal:
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • Print ISSN:
  • PII:
  • Language:
  • Keywords:
    Animals, Animals, Newborn, Astrocytes, COS Cells, Cell Communication, Cell Division, Mice, Mice, Transgenic, Nerve Net, Neurons, Phenotype, Platelet-Derived Growth Factor, Rats, Receptor, Platelet-Derived Growth Factor alpha, Receptors, Platelet-Derived Growth Factor, Retina, Retinal Vessels
Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. To test this, we inhibited PDGF signaling in the eye with a neutralizing anti-PDGFR alpha antibody or a soluble extracellular fragment of PDGFR alpha. These treatments inhibited development of the astrocyte network. We also generated transgenic mice that overexpress PDGF-A in RGCs. This resulted in hyperproliferation of astrocytes, which in turn induced excessive vasculogenesis. Thus, PDGF appears to be a link in the chain of cell-cell interactions responsible for matching numbers of neurons, astrocytes, and blood vessels during retinal development.
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