UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Sex differences in oncogenic mutational processes
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Li CH, Prokopec SD, Sun RX, Yousif F, Schmitz N, Al-Shahrour F, Atwal G, Bailey PJ, Biankin AV, Boutros PC, Campbell PJ, Chang DK, Cooke SL, Deshpande V, Faltas BM, Faquin WC, Garraway L, Getz G, Grimmond SM, Haider S, Hoadley KA, Jiao W, Kaiser VB, Karlić R, Kato M, Kübler K, Lazar AJ, Li CH, Louis DN, Margolin A, Martin S, Nahal-Bose HK, Nielsen GP, Nik-Zainal S, Omberg L, P’ng C, Perry MD, Polak P, Rheinbay E, Rubin MA, Semple CA, Sgroi DC, Shibata T, Siebert R, Smith J, Stein LD, Stobbe MD, Sun RX, Thai K, Wright DW, Wu CL, Yuan K, Zhang J, Boutros PC, Aaltonen LA, Abascal F, Abeshouse A, Aburatani H, Adams DJ, Agrawal N, Ahn KS, Ahn SM, Aikata H, Akbani R, Akdemir KC, Al-Ahmadie H, Al-Sedairy ST, Al-Shahrour F, Alawi M, Albert M, Aldape K, Alexandrov LB, Ally A, Alsop K, Alvarez EG, Amary F, Amin SB, Aminou B, Ammerpohl O, Anderson MJ, Ang Y, Antonello D, Anur P, Aparicio S, Appelbaum EL, Arai Y, Aretz A, Arihiro K, Ariizumi SI, Armenia J, Arnould L, Asa S, Assenov Y, Atwal G, Aukema S, Auman JT, Aure MR, Awadalla P, Aymerich M, Bader GD
  • Publication date:
    28/08/2020
  • Journal:
    Nature Communications
  • Volume:
    11
  • Issue:
    1
  • Status:
    Published
Abstract
© 2020, The Author(s). Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Department of Targeted Intervention
Author
Research Department of Pathology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by