© 2020 This article presents a detailed numerical flow assessment of the boundary layer and wake of a full-scale cargo ship. The assessment was conducted using a sophisticated numerical approach that is able to resolve large turbulent scale vortices contained in the flow. The physical flow features of the boundary layer and wake investigated include mean-velocity, near-wall shear stress and vorticity fields. Also, the evolution of the wake from the thick boundary layer over the stern is displayed and analysed in the highest possible detail. Additionally, the detailed information extracted from the boundary layer and wake was the primary input to assess the overall hydrodynamic efficiency of the full-scale general cargo ship. The analysis method followed during this work has been a determinant factor for fast and efficient design of energy saving devices, propellers or rudders that work within the limits of the boundary layer of a ship. In particular, this thorough analysis avoided the necessity to use the commonly used practice of trial and error that is typically followed in the maritime industry.