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Publication Detail
Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Peckham H, de Gruijter NM, Raine C, Radziszewska A, Ciurtin C, Wedderburn LR, Rosser EC, Webb K, Deakin CT
  • Publication date:
    09/12/2020
  • Pagination:
    6317
  • Journal:
    Nat Commun
  • Volume:
    11
  • Issue:
    1
  • Status:
    Published
  • Country:
    England
  • PII:
    10.1038/s41467-020-19741-6
  • Language:
    eng
Abstract
Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes. Here, we present a meta-analysis of 3,111,714 reported global cases to demonstrate that, whilst there is no difference in the proportion of males and females with confirmed COVID-19, male patients have almost three times the odds of requiring intensive treatment unit (ITU) admission (OR = 2.84; 95% CI = 2.06, 3.92) and higher odds of death (OR = 1.39; 95% CI = 1.31, 1.47) compared to females. With few exceptions, the sex bias observed in COVID-19 is a worldwide phenomenon. An appreciation of how sex is influencing COVID-19 outcomes will have important implications for clinical management and mitigation strategies for this disease.
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