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Publication Detail
A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma-like features and Nuclear Clusters (DGONC).
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Pickles JC, Mankad K, Aizpurua M, Paine SM, Bridges LR, Carceller F, Szychot E, Walker M, Fairchild AR, Mistry T, Ogunbiyi O, Rolland A, Stone TJ, Dryden C, Addy D, Garimberti E, Chalker J, Sahm F, Jones DT, Hargrave D, Jacques TS
  • Publication date:
    01/04/2021
  • Journal:
    Neuropathol Appl Neurobiol
  • Status:
    Published
  • Country:
    England
  • Language:
    eng
  • Keywords:
    DNA methylation classification, brain tumour, glioneuronal tumour, monosomy 14, paediatric
Abstract
We read with interest Deng et al.'s recent manuscript concerning a newly molecularly defined glioneuronal CNS tumour entity, termed diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC)(1). DGONCs were identified by a distinctive methylation profile that segregated away from previously recognised molecular groups of CNS tumours. On further review, the authors describe DGONCs as a novel glioneuronal tumour with key neuropathological features including oligodendroglioma-like perinuclear halos and nuclear clusters.
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Developmental Biology & Cancer Dept
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Developmental Biology & Cancer Dept
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Developmental Biology & Cancer Dept
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