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Publication Detail
Near-infrared photoimmunoTherapy (NIR-PIT) for the local control of solid cancers: challenges and potentials for human applications.
Abstract
Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer-targeted treatment effected by a chemical conjugation between a photosensitiser (e.g. the NIR phthalocyanine dye IRDye700DX) and a cancer-targeting moiety (e.g. a monoclonal antibody, moAb). Delivery of a conjugate in vivo leads to accumulation at the tumour cell surface by binding to cell surface receptors or antigens. Upon deployment of focal NIR-light, irradiation of the conjugate results in a rapid, targeted cell death. However, the mechanisms of action to produce the cytotoxic effects have yet to be fully understood. Herein, we bring together the current knowledge of NIR-PIT from preclinical and clinical studies in a variety of cancers highlighting the key unanswered research questions. Furthermore, we discuss how to enhance the local control of solid cancers using this novel treatment regimen.
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Developmental Biology & Cancer Dept
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Developmental Biology & Cancer Dept
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Developmental Biology & Cancer Dept
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Dept of Med Phys & Biomedical Eng
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