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Publication Detail
Similarities and Differences Between Juvenile and Adult Spondyloarthropathies
  • Publication Type:
    Journal article
  • Authors:
    Fisher C, Ciurtin C, Leandro M, Sen D, Wedderburn LR
  • Publication date:
  • Journal:
    Frontiers in Medicine
  • Volume:
  • Article number:
  • Status:
  • Language:
  • Keywords:
    juvenile spondyloarthropathy, enthesitis related arthritis, adolescence, enthesitis, adult spondyloarthropathy
  • Notes:
    © 2021 Fisher, Ciurtin, Leandro, Sen and Wedderburn. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Spondyloarthritis (SpA) encompasses a broad spectrum of conditions occurring from childhood to middle age. Key features of SpA include axial and peripheral arthritis, enthesitis, extra-articular manifestations, and a strong association with HLA-B27. These features are common across the ages but there are important differences between juvenile and adult onset disease. Juvenile SpA predominantly affects the peripheral joints and the incidence of axial arthritis increases with age. Enthesitis is important in early disease. This review article highlights the similarities and differences between juvenile and adult SpA including classification, pathogenesis, clinical features, imaging, therapeutic strategies, and disease outcomes. In addition, the impact of the biological transition from childhood to adulthood is explored including the importance of musculoskeletal and immunological maturation. We discuss how the changes associated with adolescence may be important in explaining age-related differences in the clinical phenotype between juvenile and adult SpA and their implications for the treatment of juvenile SpA.
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