This paper evaluates experimentally a centralized radio access network (C-RAN) based on multi-core fiber (MCF) for the transmission of high-bandwidth signals in the sub-THz band. We compare the system performance when the data and carrier wavelengths to be mixed at the receiver for optical heterodyning are transmitted over the same or over different cores of a MCF link. Full-duplex transmission on MCF is evaluated using the same received wireless signal downconverted and transmitted back as uplink over the same carrier wavelength. The performance with different digital signal processing (DSP) configurations and with higher-power interference in the other cores are also analyzed in this work. Successful provision of 12.5 GBd 16QAM signals is achieved after 1-km of 7-core MCF transmission including a short wireless link at 182 GHz, obtained with optical heterodyning. C-RAN implementation with MCF simplifies the remote nodes as all the lasers can be located in the central office, while minimizing the number of lasers needed at the central office thanks to wavelength re-use. It also provides more flexibility to the system, as it enables using the same LO for different purposes (i.e. THz generation of other data or optical modulation for uplink transmission). © 2021 SPIE.