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Publication Detail
Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior
  • Publication Type:
    Journal article
  • Authors:
    Magno L, Asgarian Z, Pendolino V, Velona T, Mackintosh A, Lee F, Stryjewska A, Zimmer C, Guillemot F, Farrant M, Clark B, Kessaris N
  • Publication date:
  • Journal:
    Cell Reports
  • Volume:
  • Issue:
  • Article number:
  • Status:
  • Country:
    United States
  • PII:
  • Language:
  • Keywords:
    Cux2, GABAergic interneurons, Pten, behavior, cortex, mouse, neurodevelopmental disorders, parvalbumin, proliferation
  • Notes:
    Copyright © 2021 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Cortical GABAergic interneurons are generated in large numbers in the ganglionic eminences and migrate into the cerebral cortex during embryogenesis. At early postnatal stages, during neuronal circuit maturation, autonomous and activity-dependent mechanisms operate within the cortex to adjust cell numbers by eliminating naturally occurring neuron excess. Here, we show that when cortical interneurons are generated in aberrantly high numbers—due to a defect in precursor cell proliferation during embryogenesis—extra parvalbumin interneurons persist in the postnatal mouse cortex during critical periods of cortical network maturation. Even though cell numbers are subsequently normalized, behavioral abnormalities remain in adulthood. This suggests that timely clearance of excess cortical interneurons is critical for correct functional maturation of circuits that drive adult behavior.
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Neuro, Physiology & Pharmacology
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