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Publication Detail
The contemporary role of MRI in the monitoring and management of people with multiple sclerosis in the UK
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Fernandesa L, Martin Allen C, Williams T, Tallantyre E, Evangelou N, Chataway J, Ford HL, UK MS Trials and Registries Consortium investigators
  • Publication date:
    01/10/2021
  • Journal:
    Multiple Sclerosis and Related Disorders
  • Volume:
    55
  • Status:
    Published
  • Print ISSN:
    2211-0348
Abstract
Background: Compare the contemporary use of magnetic resonance imaging (MRI) in the monitoring and management of people with MS in the UK to current consensus guidelines. Methods: This retrospective multicentre audit of clinical practice gathered data on 2567 patients with MS from 25 MS centres across the UK. Results: Routine monitoring (44.7%), and recent clinical relapse (20.3%) were the most common scan indications. In routine monitoring, the addition of spinal imaging to brain showed no significant difference in disease modifying treatment (DMT) decision at subsequent clinical review. Approximately 1 in 5 gadolinium administered scans showed enhancement, and in 1 in 20 patients, gadolinium enhancement was the only evidence of radiological disease activity. Mean inter-scan intervals in relapsing-remitting MS for routine monitoring was 19.2 months (SD 20.7) with wide variation between centres. Only 53.8% of patients under progressive multifocal leukoencephalopathy (PML) surveillance met the recommended scanning frequency. MRI protocols demonstrated heterogeneity in the sequences used for diagnostic, monitoring and PML surveillance scans. Conclusions: MS centres across the UK demonstrate varied practice and protocols when using MRI to monitor people with MS. In this cohort, gadolinium use and spinal imaging demonstrates limited impact on subsequent DMT decisions.
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