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Publication Detail
Quantitative Susceptibility Mapping (QSM) is Sensitive to Hippocampal and Subcortical Gray Matter Changes in Temporal Lobe Epilepsy
  • Publication Type:
    Conference presentation
  • Authors:
    Kiersnowski OC, Winston GP, Biondetti E, Buck S, Caciagli L, Duncan J, Shmueli K, Vos SB
  • Date:
    15/05/2021
  • Name of Conference:
    ISMRM & SMRT Annual Meeting & Exhibition 2021
  • Conference start date:
    15/05/2021
  • Conference finish date:
    20/05/2021
  • Keywords:
    Epilepsy, Temporal lobe epilepsy, Quantitative susceptibility mapping, QSM, Susceptibility
Abstract
Although temporal lobe epilepsy (TLE) results in widespread changes in MRI measures of tissue volume, diffusion and functional connectivity, changes in tissue composition in TLE have not been investigated with MRI. Quantitative susceptibility mapping (QSM) is sensitive to changes in tissue composition, in particular to iron and myelin. Here, we show for the first time that QSM is sensitive to gray matter abnormalities in 31patients with temporal lobe epilepsy (TLE) compared to 23 healthy controls, and showed significant susceptibility changes in the hippocampus in left TLE patients, and in the bilateral thalamus in both left and right TLE.
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Clinical & Experimental Epilepsy
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Dept of Med Phys & Biomedical Eng
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Dept of Med Phys & Biomedical Eng
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UCL Queen Square Institute of Neurology
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