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Publication Detail
Geographical drivers and climate-linked dynamics of Lassa fever in Nigeria.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Redding DW, Gibb R, Dan-Nwafor CC, Ilori EA, Yashe RU, Oladele SH, Amedu MO, Iniobong A, Attfield LA, Donnelly CA, Abubakar I, Jones KE, Ihekweazu C
  • Publication date:
  • Pagination:
    5759, ?
  • Journal:
    Nat Commun
  • Volume:
  • Issue:
  • Status:
    Published online
  • Country:
  • PII:
  • Language:
  • Keywords:
    Animals, Climate, Disease Reservoirs, Epidemiological Monitoring, Geography, Humans, Incidence, Lassa Fever, Lassa virus, Murinae, Nigeria, Poverty, Retrospective Studies, Spatio-Temporal Analysis, Urbanization
Lassa fever is a longstanding public health concern in West Africa. Recent molecular studies have confirmed the fundamental role of the rodent host (Mastomys natalensis) in driving human infections, but control and prevention efforts remain hampered by a limited baseline understanding of the disease's true incidence, geographical distribution and underlying drivers. Here, we show that Lassa fever occurrence and incidence is influenced by climate, poverty, agriculture and urbanisation factors. However, heterogeneous reporting processes and diagnostic laboratory access also appear to be important drivers of the patchy distribution of observed disease incidence. Using spatiotemporal predictive models we show that including climatic variability added retrospective predictive value over a baseline model (11% decrease in out-of-sample predictive error). However, predictions for 2020 show that a climate-driven model performs similarly overall to the baseline model. Overall, with ongoing improvements in surveillance there may be potential for forecasting Lassa fever incidence to inform health planning.
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