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Publication Detail
Studying Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis with 7-T magnetic resonance
  • Publication Type:
    Journal article
  • Authors:
    Düzel E, Costagli M, Donatelli G, Speck O, Cosottini M
  • Publication date:
    01/12/2021
  • Journal:
    European Radiology Experimental
  • Volume:
    5
  • Issue:
    1
  • Article number:
    36
  • Status:
    Published
  • Language:
    English
  • Keywords:
    Alzheimer disease, Amyotrophic lateral sclerosis, Magnetic resonance imaging, Neurodegenerative diseases, Parkinson disease
  • Notes:
    This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Abstract
Ultra-high-field (UHF) magnetic resonance (MR) scanners, that is, equipment operating at static magnetic field of 7 tesla (7 T) and above, enable the acquisition of data with greatly improved signal-to-noise ratio with respect to conventional MR systems (e.g., scanners operating at 1.5 T and 3 T). The change in tissue relaxation times at UHF offers the opportunity to improve tissue contrast and depict features that were previously inaccessible. These potential advantages come, however, at a cost: in the majority of UHF-MR clinical protocols, potential drawbacks may include signal inhomogeneity, geometrical distortions, artifacts introduced by patient respiration, cardiac cycle, and motion. This article reviews the 7 T MR literature reporting the recent studies on the most widespread neurodegenerative diseases: Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.
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