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Publication Detail
Ripple band phase precession of place cell firing during replay
  • Publication Type:
    Journal article
  • Authors:
    Bush D, Ólafsdóttir HF, Barry C, Burgess N
  • Publisher:
    Elsevier BV
  • Publication date:
    11/2021
  • Journal:
    Current Biology
  • Status:
    Accepted
  • Print ISSN:
    0960-9822
  • Language:
    English
  • Keywords:
    hippocampus, replay, sharp-wave ripples, place cells, theta oscillations, phase coding
  • Notes:
    2021 The Author(s). Published by Elsevier Inc. 1 This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Abstract
Neuronal “replay,” in which place cell firing during rest recapitulates recently experienced trajectories, is thought to mediate the transmission of information from hippocampus to neocortex, but the mechanism for this transmission is unknown. Here, we show that replay uses a phase code to represent spatial trajectories by the phase of firing relative to the 150- to 250-Hz “ripple” oscillations that accompany replay events. This phase code is analogous to the theta phase precession of place cell firing during navigation, in which place cells fire at progressively earlier phases of the 6- to 12-Hz theta oscillation as their place field is traversed, providing information about self-location that is additional to the rate code and a necessary precursor of replay. Thus, during replay, each ripple cycle contains a “forward sweep” of decoded locations along the recapitulated trajectory. Our results indicate a novel encoding of trajectory information during replay and implicates phase coding as a general mechanism by which the hippocampus transmits experienced and replayed sequential information to downstream targets.
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