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Publication Detail
Updates on the antiphospholipid syndrome
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Clark KE, Giles I
  • Publication date:
  • Journal:
    Medicine (United Kingdom)
  • Status:
  • Print ISSN:
Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia characterized by venous or arterial thrombosis, and/or pregnancy loss or complications in the presence of persistently positive antiphospholipid antibodies. Organ involvement, referred to as non-criteria manifestations, includes livedo reticularis, thrombocytopenia and nephropathy. Non-thrombotic inflammatory mechanisms are increasingly identified in the pathogenesis of APS, alongside a recognition that obstetric APS might be a specific subset of APS. Treatment remains focused on life-long anticoagulation and prevention of further thrombosis or obstetric complications. Identification of novel mechanisms is, however, leading the development of diagnostic tests and more targeted therapies to improve disease management.
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