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Publication Detail
Structure of an antibody combining site by magnetic resonance
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Publication Type:Journal article
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Publication Sub Type:Journal Article
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Authors:Dwek RA, Wain-Hobson S, Dower S, Gettins P, Sutton B, Perkins SJ, Givol D
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Publication date:01/12/1977
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Pagination:31, 37
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Journal:Nature
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Volume:266
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Issue:5597
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Status:Published
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Print ISSN:0028-0836
Abstract
The structure of the combining site of the DNP binding IgA mouse myeloma protein MOPC 315 has been determined by a combination of high resolution nuclear magnetic resonance, electron spin resonance, model building and chemical modifications. This approach yields the general dimensions of the site, its polarity and asymmetry features, the assignment of the DNP-contact residues and their three-dimensional coordinates. © 1977 Nature Publishing Group.
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