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Publication Detail
The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Brissett NC, Perkins SJ
  • Publication date:
  • Pagination:
    211, 216
  • Journal:
    FEBS Letters
  • Volume:
  • Issue:
  • Status:
  • Print ISSN:
Link protein and aggrecan of the extracellular matrix each contain two proteoglycan tandem repeat (PTR) domains that interact with hyaluronate. Consensus secondary structure predictions for 59 PTR sequences and 129 C-type lectin sequences give similar patterns of two α-helices and up to seven β-strands. Protein fold recognition analyses show that the 59 PTR sequences are highly compatible with the C-type lectin crystal structure. The predicted fold consists of a conserved motif formed from an antiparallel β-sheet flanked by two α-helices, the motif being attached to two distinct types of β-sheet region in the two superfamilies. Arg9 or Lys11 on an exposed loop and up to three other Arg residues in the β-sheet region are conserved and may form part of a hyaluronate binding site.
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