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Publication Detail
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Bhandari R, Saiardi A, Ahmadibeni Y, Snowman AM, Resnick AC, Kristiansen TZ, Molina H, Pandey A, Werner JK, Juluri KR, Xu Y, Prestwich GD, Parang K, Snyder SH
  • Publisher:
    NATL ACAD SCIENCES
  • Publication date:
    25/09/2007
  • Pagination:
    15305, 15310
  • Journal:
    P NATL ACAD SCI USA
  • Volume:
    104
  • Issue:
    39
  • Print ISSN:
    0027-8424
  • Language:
    EN
  • Keywords:
    inositol polyphosphate, protein phosphorylation, HEXAKISPHOSPHATE KINASE-2, TELOMERE LENGTH, CELL-DEATH, PENTAKISPHOSPHATE, PHOSPHORYLATION, METABOLISM, NUCLEOLUS, INTEGRITY, NOPP140, FAMILY
  • Addresses:
    Johns Hopkins Univ
    Sch Med
    Dept Neurosci
    Baltimore
    MD
    21205
    USA

    Johns Hopkins Univ
    Sch Med
    Dept Pharmacol & Mol Sci
    Baltimore
    MD
    21205
    USA

    Johns Hopkins Univ
    Sch Med
    Dept Psychiat & Behav Sci
    Baltimore
    MD
    21205
    USA

    Johns Hopkins Univ
    Sch Med
    Nathans Inst Genet Med
    Baltimore
    MD
    21205
    USA

    Johns Hopkins Univ
    Sch Med
    Dept Biol Chem
    Baltimore
    MD
    21205
    USA

    UCL
    Dept Biochem & Mol Biol
    Mol Cell Biol Lab
    London
    WC1E 6BT
    England

    UCL
    MRC
    Cell Biol Unit
    London
    WC1E 6BT
    England

    Univ Rhode Isl
    Coll Pharm
    Dept Biomed & Pharmaceut Sci
    Kingston
    RI
    02881
    USA

    Univ Utah
    Dept Med Chem
    Salt Lake City
    UT
    84108
    USA
Abstract
In a previous study, we showed that the inositol pyrophosphate diphosphoinositol pentakisphosphate (IP7) physiologically phosphorylates mammalian and yeast proteins. We now report that this phosphate transfer reflects pyrophosphorylation. Thus, proteins must be prephosphorylated by ATIP to prime them for IP7 phosphorylation. IP7 phosphorylates synthetic phosphopeptides but not if their phosphates have been masked by methylation or pyrophosphorylation. Moreover, IP7 phosphorylated peptides are more acid-labile and more resistant to phosphatases than ATIP phosphorylated peptides, indicating a different type of phosphate bond. Pyrophosphorylation may represent a novel mode of signaling to proteins.
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