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Publication Detail
A High-Throughput In Vitro Radiobiology Platform for Megavoltage Photon Linear Accelerator Studies
  • Publication Type:
    Journal article
  • Authors:
    Thippu Jayaprakash K, Mostafa D, Hussein M, Shaffer R, Michael A, Ajaz M, Nisbet A
  • Publisher:
  • Publication date:
  • Journal:
    Applied Sciences
  • Volume:
  • Issue:
  • Article number:
  • Status:
  • Language:
  • Keywords:
    intensity-modulated radiotherapy, in vitro radiobiology platform, personalised radiotherapy, preclinical radiotherapy studies, radiation-drug combinations
  • Notes:
    This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
We designed and developed a multiwell tissue culture plate irradiation setup, and intensity modulated radiotherapy plans were generated for 96-, 24-, and 6-well tissue culture plates. We demonstrated concordance between planned and measured/imaged radiation dose profiles using radiochromic film, a 2D ion chamber array, and an electronic portal-imaging device. Cell viability, clonogenic potential, and γ-H2AX foci analyses showed no significant differences between intensity-modulated radiotherapy and open-field, homogeneous irradiations. This novel platform may help to expedite radiobiology experiments within a clinical environment and may be used for wide-ranging ex vivo radiobiology applications.
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