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Publication Detail
Use of anti-citrullinated peptide and anti-RA33 antibodies in distinguishing erosive arthritis in patients with systemic lupus erythematosus and rheumatoid arthritis
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Mediwake R, Isenberg DA, Schellekens GA, van Venrooij WJ
  • Publication date:
  • Pagination:
    67, 68
  • Journal:
    Annals of the Rheumatic Diseases
  • Volume:
  • Issue:
  • Print ISSN:
  • Keywords:
    antibodies, Antibodies, Antinuclear, Antibody, ANTINUCLEAR, Arthritis, Arthritis, Rheumatoid, As, Autoantibodies, Biological Markers, Blood, Citrulline, diagnosis, Diagnosis, Differential, disease, Diseases, FOLLOW, FOLLOW UP, Follow-up, Follow-Up Studies, Hand, hands, IM, immunology, JOINT, Joints, LA, LONG, long term follow up, LONG-TERM, Lupus, Lupus Erythematosus, Systemic, MARKER, Markers, May, Methods, ONSET, Patient, patients, peptide, positive, Result, Retrospective Studies, Rheumatoid arthritis, Rheumatoid Factor, RHEUMATOID-ARTHRITIS, Rheumatology, SLE, small, Support, Non-U.S.Gov't, SYSTEMIC, SYSTEMIC LUPUS ERYTHEMATOSUS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, TERM, TERM FOLLOW UP, Use
  • Notes:
    UI - 20566406 LA - eng RN - 0 (Antibodies, Antinuclear) RN - 0 (Autoantibodies) RN - 0 (Biological Markers) RN - 372-75-8 (Citrulline) RN - 9009-79-4 (Rheumatoid Factor) PT - Journal Article DA - 20010104 IS - 0003-4967 SB - IM CY - ENGLAND
OBJECTIVES: Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) can both present with an erosive arthritis with the small joints of the hands affected. Therefore a serological marker would be useful to distinguish between these two diseases at onset. In this study anti- RA33 antibodies, which are found in patients with SLE and RA, and anti- citrullinated peptide antibodies (anti-CCP), which have recently been described as highly specific for RA, were assessed. METHODS: Two hundred and thirty one patients receiving long term follow up for SLE were evaluated for arthritis and classified as erosive and non-erosive disease. Sixty six patients were tested for anti-RA33 and anti-CCP antibodies. All the patients were tested for rheumatoid factor (RF) and HLA-DR4 status. RESULTS: Ten patients had erosive disease, six of whom were RF positive (60%), and six anti-RA33 positive (60%), whereas only two were anti-CCP positive (20%). Two hundred and twenty one patients had non-erosive disease, 40 of whom were RF positive (18%), 14 were anti-RA33 positive (6%), whereas only one patient was found to be anti- CCP positive (0.5%). CONCLUSION: The presence of anti-CCP antibodies may be useful in distinguishing RA from erosive SLE. Anti-RA33 antibodies and RF are unhelpful
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