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Publication Detail
Genome-Edited T Cell Therapies.
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Ottaviano G, Qasim W
  • Publisher:
    WB Saunders
  • Publication date:
  • Journal:
    Hematology / Oncology Clinics of North America
  • Status:
    Published online
  • Country:
    United States
  • Print ISSN:
  • PII:
  • Language:
  • Keywords:
    Base editor, CRISPR/Cas9, Chimeric antigen receptor, Cytidine deamination, Genome editing, T cell therapies
Chimeric antigen receptor (CAR) T-cells are widely being investigated against malignancies, and allogeneic 'universal donor' CAR-T cells offer the possibility of widened access to pre-manufactured, off-the-shelf therapies. Different genome-editing platforms have been used to address human leukocyte antigen (HLA) barriers to generate universal CAR-T cell therapy and early applications have been reported in children and adults against B cell malignancies. Recently developed Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based systems and related technologies offer the prospect of enhanced cellular immunotherapies for a wider range of hematological malignancies.
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