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Publication Detail
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas
  • Publication Type:
    Journal article
  • Authors:
    Ng AWT, Contino G, Killcoyne S, Devonshire G, Hsu R, Abbas S, Su J, Redmond AM, Weaver JMJ, Eldridge MD, Tavaré S, Grehan N, Nutzinger B, Fidziukiewicz E, Freeman A, Smyth EC, O’Donovan M, Miremadi A, Malhotra S, Tripathi M, Cheah C, Coles H, Flint C, Eldridge M, Secrier M, Jammula S, Davies J, Crichton C, Carroll N, Hardwick RH, Safranek P, Hindmarsh A, Sujendran V, Hayes SJ, Ang Y, Sharrocks A, Preston SR, Bagwan I, Save V, Skipworth RJE, Hupp TR, O’Neill JR, Tucker O, Beggs A, Taniere P, Puig S, Underwood TJ, Walker RC, Grace BL, Lagergren J, Gossage J, Davies A, Chang F, Mahadeva U, Goh V, Ciccarelli FD, Sanders G, Berrisford R, Chan D, Cheong E, Kumar B, Sreedharan L, Parsons SL, Soomro I, Kaye P, Saunders J, Lovat L, Haidry R, Scott M, Sothi S, Lishman S, Hanna GB, Peters CJ, Moorthy K, Grabowska A, Turkington R, McManus D, Coleman H, Petty RD, Bartlett F, Edwards PAW, Fitzgerald RC
  • Publisher:
    Springer Science and Business Media LLC
  • Publication date:
  • Journal:
    Communications Biology
  • Volume:
  • Issue:
  • Article number:
  • Medium:
  • Status:
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  • Keywords:
    Adenocarcinoma, Esophageal Neoplasms, Genome, Human, Histone Acetyltransferases, Humans, Whole Genome Sequencing
  • Notes:
    This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched whole transcriptomes, we observed structural variations (SV) with a predominance of deletions, tandem duplications and inter-chromosome junctions that could be identified as LINE-1 mobile element (ME) insertions. Complex clusters of rearrangements resembling breakage-fusion-bridge cycles or extrachromosomal circular DNA accounted for 22% of complex SVs affecting known oncogenes. Counting SV events affecting known driver genes substantially increased the recurrence rates of these drivers. After excluding fragile sites, we identified 51 candidate new drivers in genomic regions disrupted by SVs, including ETV5, KAT6B and CLTC. RUNX1 was the most recurrently altered gene (24%), with many deletions inactivating the RUNT domain but preserved the reading frame, suggesting an altered protein product. These findings underscore the importance of identification of SV events in OAC with implications for targeted therapies.
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