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Publication Detail
Evidence for anti-osteoporosis therapy in acute fracture situations-Recommendations of a multidisciplinary workshop of the International Society for Fracture Repair
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Goldhahn J, Little D, Mitchell P, Fazzalari N, Reid IR, Aspenberg P, Marsh D, ISFR Working Grp Drugs Fracture Re
  • Publisher:
    ELSEVIER SCIENCE INC
  • Publication date:
    02/2010
  • Pagination:
    267, 271
  • Journal:
    BONE
  • Volume:
    46
  • Issue:
    2
  • Print ISSN:
    8756-3282
  • Language:
    EN
  • Keywords:
    Fracture healing, Osteoporosis, Drugs, Drug interaction, PARATHYROID-HORMONE 1-34, WORLDWIDE PREVALENCE, POSTMENOPAUSAL WOMEN, FRAGILITY FRACTURE, ZOLEDRONIC ACID, ANIMAL-MODELS, ALENDRONATE, BONE, RATS, RISK
  • Addresses:
    Goldhahn, J
    Schulthess Klin Zurich
    Zurich
    Switzerland
Abstract
The International Society for Fracture Repair convened a multidisciplinary workshop to assess the current evidence around the interaction between anti-osteoporosis drugs and the healing of incident fractures, with a view to making recommendations for clinical practice. The consensus was that there is no evidence-based reason to withhold anti-resorptive therapy while a fracture heals, whether or not the patient was taking such therapy when the fracture occurred. The workshop also considered existing models of service provision for secondary prevention and concluded that the essential ingredient for reliable delivery is the inclusion of a dedicated coordinator role. Several unresolved issues were defined as subjects for further research, including the question of whether continuous long-term administration of anti-resorptives may impair bone quality. The rapidly changing area requires re-assessment of drugs and their interaction with fracture healing in the near future. (C) 2009 Elsevier Inc. All rights reserved.
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Inst of Orthopaedics & Musculosk Sci
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