In this chapter we bring together research from the domains of social networks, resilience and spatial morphology to argue that the built environment is an often overlooked but increasingly recognised vector influencing the formation of ties in social networks. We define space on different scales – the urban and interior – as opportunity structures supporting or undermining network resilience, i.e., the way in which access to resources is enabled. A literature review identified five different spatial mechanisms with the power to inhibit resilience in social networks: proximity, correspondence, severance, access inequality and uniformity. Finally, we present empirical work that conceptualizes urban and architectural opportunity structures for the elderly in care homes in Nanjing, China. We close with a research agenda on socio-spatial resilience.