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Publication Detail
Elevated Levels of the 90 kDa Heat Shock Protein (hsp90) in SLE Correlate with Levels of IL-6 and Autoantibodies to hsp90
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Ripley BJ, Isenberg DA, Latchman DS
  • Publication date:
  • Pagination:
    341, 346
  • Journal:
    Journal of Autoimmunity
  • Volume:
  • Issue:
  • Print ISSN:
  • Keywords:
    Autoantibodies, CORRELATE, Heat, Hsp90, IL-6, LEVEL, MB, PROTEIN, Shock, SLE, cell, CELLS, Child, control, cultured cells, enhanced, EXPOSURE, GENE, health, IgG, IL-10, IM, INDUCE, LA, Lupus, model, Patient, patients, production, Result, support, SYSTEMIC, SYSTEMIC LUPUS ERYTHEMATOSUS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, TRANSCRIPTION
  • Notes:
    UI - 21634816 LA - eng PT - Journal Article DA - 20020104 IS - 0896-8411 SB - IM CY - England
Levels of the 90 kDa heat shock protein (hsp90) are elevated in a subset of patients with systemic lupus erythematosus (SLE) due to enhanced transcription of the hsp90beta gene. In cultured cells, transcription of the hsp90beta gene is induced following exposure to IL- 6 or IL-10 which are known to be elevated in SLE patients. Here we have measured the levels of hsp90 protein and of IL-6, IL-10 in SLE patients and normal controls. We demonstrate that the levels of hsp90 protein in individual patients correlate with the IL-6 level but not with the level of IL-10. Moreover, hsp90 protein levels in patients correlate with the presence of IgG autoantibodies to hsp90. These results support a model in which elevated levels of IL-6 in SLE patients induce elevated levels of hsp90 protein which in turn results in the production of autoantibodies to this protein
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