UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Elevated Levels of the 90 kDa Heat Shock Protein (hsp90) in SLE Correlate with Levels of IL-6 and Autoantibodies to hsp90
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Ripley BJ, Isenberg DA, Latchman DS
  • Publication date:
    12/2001
  • Pagination:
    341, 346
  • Journal:
    Journal of Autoimmunity
  • Volume:
    17
  • Issue:
    4
  • Print ISSN:
    0896-8411
  • Keywords:
    Autoantibodies, CORRELATE, Heat, Hsp90, IL-6, LEVEL, MB, PROTEIN, Shock, SLE, cell, CELLS, Child, control, cultured cells, enhanced, EXPOSURE, GENE, health, IgG, IL-10, IM, INDUCE, LA, Lupus, model, Patient, patients, production, Result, support, SYSTEMIC, SYSTEMIC LUPUS ERYTHEMATOSUS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, TRANSCRIPTION
  • Notes:
    UI - 21634816 LA - eng PT - Journal Article DA - 20020104 IS - 0896-8411 SB - IM CY - England
Abstract
Levels of the 90 kDa heat shock protein (hsp90) are elevated in a subset of patients with systemic lupus erythematosus (SLE) due to enhanced transcription of the hsp90beta gene. In cultured cells, transcription of the hsp90beta gene is induced following exposure to IL- 6 or IL-10 which are known to be elevated in SLE patients. Here we have measured the levels of hsp90 protein and of IL-6, IL-10 in SLE patients and normal controls. We demonstrate that the levels of hsp90 protein in individual patients correlate with the IL-6 level but not with the level of IL-10. Moreover, hsp90 protein levels in patients correlate with the presence of IgG autoantibodies to hsp90. These results support a model in which elevated levels of IL-6 in SLE patients induce elevated levels of hsp90 protein which in turn results in the production of autoantibodies to this protein
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
ICH - Directors Office
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by