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Publication Detail
In vivo and in vitro studies of immunoglobulin gene somatic hypermutation
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Sale JE, Bemark M, Williams GT, Jolly CJ, Ehrenstein MR, Rada C, Milstein C, Neuberger MS
  • Publication date:
    29/01/2001
  • Pagination:
    21, 28
  • Journal:
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • Volume:
    356
  • Issue:
    1405
  • Print ISSN:
    0962-8436
  • Keywords:
    Animal, ANTIGEN, B CELL, B CELLS, B-cell, B-CELLS, Base Pairing, Biological Transport, cell, CELLS, Class, COMMON, CONSTANT REGION, difference, DISTINCT, DNA Damage, ENCOUNTER, EVENTS, EXAMPLE, GC Rich Sequence, GENE, Genes, Genes, myc, genetic, genetics, IM, IMMUNOGLOBULIN, Immunoglobulin Class Switching, Immunoglobulin Gene, IMMUNOGLOBULIN GENES, Immunoglobulin Isotypes, IMMUNOGLOBULINS, in vitro, In Vitro Study, in vivo, In-vitro, in-vivo, LA, Laboratories, May, MECHANISM, metabolism, Mutation, Other, process, processes, Recombination, Recombination, Genetic, REGION, REPERTOIRE, Research, Review, SERA, serum, SWITCH, variable, VITRO, vivo
  • Notes:
    UI - 21072330 LA - eng RN - 0 (Immunoglobulin Isotypes) RN - 0 (Immunoglobulins) PT - Journal Article PT - Review PT - Review, Tutorial DA - 20010201 IS - 0962-8436 SB - IM CY - England
Abstract
Following antigen encounter, two distinct processes modify immunoglobulin genes. The variable region is diversified by somatic hypermutation while the constant region may be changed by class-switch recombination. Although both genetic events can occur concurrently within germinal centre B cells, there are examples of each occurring independently of the other. Here we compare the contributions of class- switch recombination and somatic hypermutation to the diversification of the serum immunoglobulin repertoire and review evidence that suggests that, despite clear differences, the two processes may share some aspects of their mechanism in common
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