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Publication Detail
Damage and mortality in a group of British patients with systemic lupus erythematosus followed up for over 10 years.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Chambers SA, Allen E, Rahman A, Isenberg D
  • Publication date:
  • Pagination:
    673, 675
  • Journal:
    Rheumatology (Oxford)
  • Volume:
  • Issue:
  • Status:
  • Country:
  • PII:
  • Language:
  • Keywords:
    Adult, Cause of Death, Disease Progression, Female, Follow-Up Studies, Humans, Kidney Diseases, Lung Diseases, Lupus Erythematosus, Systemic, Male, Musculoskeletal Diseases, Neoplasms, Proportional Hazards Models, Skin Diseases, Stroke, Time Factors, United Kingdom
OBJECTIVE: To study damage accrual and mortality in British patients with SLE under long-term follow-up for >10 years. METHODS: We analysed the clinical records of 232 patients with SLE who had at least 10 years of consistent follow-up at University College London Hospital (UCLH). We noted their SLICC/ACR Damage Index (SDI) scores and category of damage at 1 year post-diagnosis of SLE and every 5 years thereafter. For patients who had died, we determined the year and cause of death. RESULTS: Ninety per cent of patients had no damage at 1 year post-diagnosis of SLE; however by year 10, 50% had accrued some damage. Damage accrual was mostly in the neuropsychiatric, renal and musculoskeletal categories. An increase in damage score was associated with a higher risk of death overall. Forty-four patients died during the period of follow-up. Sepsis, cancer and organ failure (cardiac, renal and liver) were the main causes of death in this group of patients. CONCLUSIONS: Damage accrual is associated with an increased risk of mortality. Infections remain an important cause of death in patients with SLE.
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