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Publication Detail
The effects of beta blockade on dopamine and dobutamine induced hypokalaemia in dogs.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Smith M, Drake HF, Corfield DR, Treasure T
  • Publication date:
  • Pagination:
    452, 457
  • Journal:
    Intensive Care Med
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • Print ISSN:
  • Language:
  • Keywords:
    Animals, Atenolol, Blood Pressure, Dobutamine, Dogs, Dopamine, Heart Rate, Hypokalemia, Infusions, Intravenous, Propanolamines
The effect of beta 1 and beta 2 blockade on dopamine and dobutamine induced hypokalaemia was investigated in dogs. Arterial plasma potassium was continuously monitored using a potassium-sensitive electrode sited in the abdominal aorta. Dopamine and dobutamine were infused at 15 micrograms kg-1 min-1 into animals pre-treated with atenolol (0.5 mg kg-1) or ICI 118551 (0.5 mg kg-1) and the potassium changes compared to those seen in control animals. The inotrope infusions caused a small and transient rise in plasma potassium (p less than 0.05) followed by a more profound hypokalaemia (p less than 0.05) sustained for the duration of the infusion. The potassium falls in the control animals were similar to those in the beta 1 and beta 2 blockade groups. The results suggest that beta 2 receptor stimulation cannot alone be responsible for dopamine and dobutamine induced hypokalaemia and a multiple receptor activation is postulated.
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