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Publication Detail
Cerebrovascular disease and functional outcome after coronary artery bypass surgery.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Harrison MJ, Schneidau A, Ho R, Smith PL, Newman S, Treasure T
  • Publication date:
  • Pagination:
    235, 237
  • Journal:
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • Print ISSN:
  • Language:
  • Keywords:
    Brain, Carotid Arteries, Cerebral Angiography, Cerebrovascular Disorders, Coronary Artery Bypass, Forecasting, Humans, Neuropsychological Tests, Postoperative Period, Prospective Studies, Time Factors
A series of patients undergoing coronary artery bypass surgery was studied prospectively to see if angiographic evidence of cerebrovascular disease proved predictive of the incidence of neuropsychological deficit 8 days or 8 weeks after surgery. In 47 patients, intravenous digital subtraction angiography was carried out preoperatively to assess the presence and severity of atheromatous changes in the carotid arteries; 51% had evidence of vessel wall disease and 17% had stenosis of at least one carotid artery in the neck, although only one patient had severe narrowing. Overall, 77% of these 47 patients showed a neuropsychological deficit as defined by a significantly reduced score in at least two of 10 tests administered 8 days after surgery. Eight weeks after surgery 36% still showed a deficit. The incidence of neuropsychological deficit was not significantly greater among those patients with angiographically visible carotid artery disease. The mechanism of surgery-related cognitive impairment is briefly discussed in the light of these findings.
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