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Publication Detail
Cutting edge: selection of B lymphocyte subsets is regulated by natural IgM
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Baker N, Ehrenstein MR
  • Publication date:
    15/12/2002
  • Pagination:
    6686, 6690
  • Journal:
    The Journal of Immunology
  • Volume:
    169
  • Issue:
    12
  • Print ISSN:
    0022-1767
  • Keywords:
    Administration, Animal, antibodies, Antibodies, Monoclonal, Antibody, Antigen-Antibody Reactions, B CELL, B CELLS, B Lymphocyte, B-cell, B-CELLS, B-lymphocyte, B-Lymphocyte Subsets, Blood, cell, Cell Differentiation, Cell Division, CELL-RECEPTOR, CELLS, Clone Cells, Crosses, Genetic, cytology, deficiency, endogenous, EXPANSION, follicular, formation, genetics, growth, Growth Inhibitors, Igm, IM, immune, Immune Sera, Immune System, IMMUNE-SYSTEM, IMMUNOGLOBULIN, Immunoglobulin M, immunology, INCREASE, INHIBITOR, INHIBITORS, LA, LYMPHOCYTE, Lymphocyte Count, LYMPHOCYTE SUBSETS, M, membrane, metabolism, mice, Mice, Inbred C57BL, Mice, Transgenic, physiology, RANGE, RATIO, Receptor, REDUCTION, REPERTOIRE, Result, selection, serum, Spleen, SUBSETS, Support, Non-U.S.Gov't, SYSTEM
  • Notes:
    UI - 22359184 DA - 20021209 IS - 0022-1767 LA - eng PT - Journal Article RN - 0 (Antibodies, Monoclonal) RN - 0 (Growth Inhibitors) RN - 0 (Immune Sera) RN - 0 (Immunoglobulin M) SB - AIM SB - IM
Abstract
Natural IgM has a wide range of actions in the immune system. Here we demonstrate that mice lacking serum IgM have an expansion in splenic marginal zone B cells with a proportionately smaller reduction in follicular B cells. The increase in the marginal zone-follicular B cell ratio (and an expansion in peritoneal B1a cells) is fully reversed by administration of polyclonal IgM, but not by two IgM monoclonals. Mice engineered to have a secreted oligoclonal IgM repertoire with an endogenous membrane IgM also exhibited a similar expansion of marginal zone B cells. We propose that natural IgM, by virtue of its polyreactivity, enhances Ag-driven signaling through the B cell receptor and promotes the formation of follicular B cells. These results demonstrate that natural IgM regulates the selection of B lymphocyte subsets
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