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Publication Detail
A comparison of depression, anxiety, and health status in patients with progressive supranuclear palsy and multiple system atrophy.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Comparative Study
  • Authors:
    Schrag A, Sheikh S, Quinn NP, Lees AJ, Selai C, Mathias C, Litvan I, Lang AE, Bower JH, Burn DJ, Low P, Jahanshahi M
  • Publication date:
  • Pagination:
    1077, 1081
  • Journal:
    Mov Disord
  • Volume:
  • Issue:
  • Status:
  • Country:
    United States
  • Language:
  • Keywords:
    Aged, Anxiety, Depression, Factor Analysis, Statistical, Female, Health Status, Health Surveys, Humans, Male, Middle Aged, Multiple System Atrophy, Pain Measurement, Psychiatric Status Rating Scales, Statistics, Nonparametric, Supranuclear Palsy, Progressive
The objective of this study was to compare subjective health status and its correlates in progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). One hundred eighty-eight patients with PSP and 286 patients with MSA completed EQ-5D and Hospital Depression and Anxiety Scale. The impact on mobility, usual activities, and self-care was similarly high in both groups after similar duration. Fifty-six percent of PSP and 43% of MSA had probable depression, and 37% of both groups had probable anxiety. Patients with PSP had significantly higher depression scores, but groups did not differ in anxiety scores. Patients with MSA had significantly greater pain/discomfort than patients with PSP. The most important association with subjective health status was with depressive symptoms, which accounted for 38% and 29% of EQ-5D variance in patients with PSP and MSA, followed by disease severity and anxiety scores. We conclude that depressive symptoms were common in both disorders, but more severe in PSP. Anxiety symptoms affected 37% of patients in both groups and contributed to impaired subjective health status. Pain was more problematic in MSA than PSP.
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UCL Queen Square Institute of Neurology
Clinical and Movement Neurosciences
UCL Queen Square Institute of Neurology
Clinical and Movement Neurosciences
Clinical and Movement Neurosciences
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