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Publication Detail
Development of the hippocampal cognitive map in preweanling rats.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Wills TJ, Cacucci F, Burgess N, O'Keefe J
  • Publication date:
    18/06/2010
  • Pagination:
    1573, 1576
  • Journal:
    Science
  • Volume:
    328
  • Issue:
    5985
  • Status:
    Published
  • Country:
    United States
  • PII:
    328/5985/1573
  • Language:
    eng
  • Keywords:
    Action Potentials, Aging, Animals, Animals, Suckling, Brain Mapping, CA1 Region, Hippocampal, Cognition, Electrodes, Implanted, Entorhinal Cortex, Exploratory Behavior, Male, Neurons, Orientation, Pyramidal Cells, Rats, Space Perception, Spatial Behavior, Theta Rhythm
Abstract
Orienting in large-scale space depends on the interaction of environmental experience and preconfigured, possibly innate, constructs. Place, head-direction, and grid cells in the hippocampal formation provide allocentric representations of space. Here we show how these cognitive representations emerge and develop as rat pups first begin to explore their environment. Directional, locational, and rhythmic organization of firing are present during initial exploration, including adultlike directional firing. The stability and precision of place cell firing continue to develop throughout juvenility. Stable grid cell firing appears later but matures rapidly to adult levels. Our results demonstrate the presence of three neuronal representations of space before extensive experience and show how they develop with age.
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