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Publication Detail
Propagation-Based Morphometry in an Ex Vivo Mouse Embryo Atlas - Assessment and Validation
  • Publication Type:
  • Authors:
    Norris FC, Cleary JO, Modat M, Price AN, McCue K, Beddow S, Scambler PJ, Ourselin S, Lythgoe MF
  • Publication date:
  • Published proceedings:
    Proceedings 18th Scientific Meeting, International Society for Magnetic Resonance in Medicine, Stockholm
  • Notes:
    date-added: 2010-05-25 17:39:28 +0100 date-modified: 2010-07-13 11:10:23 +0100 uri: papers://0E4B006B-D044-4501-93CA-AAE1F0F87354/Paper/p10900 rating: 0
The increasing use of genetically modified mice has highlighted the need for effective phenotyping methods. Propagation-based morphometry (PBM) is an emerging technique enabling non-invasive and rapid acquisition of volumetric data using an average population atlas for morphometric analysis. Thus, PBM shows promise for combining high-throughput ┬ÁMR imaging of late-gestation embryos with high-throughput analysis. We present the first study to assess and validate the accuracy of volumes generated via PBM in an ex vivo mouse embryo atlas comprising three different groups. Preliminary results show promise towards the broad applicability of this technique for phenotyping mutant mouse models.
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