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Publication Detail
Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Cohen M, Georgiou M, Stevenson NL, Miodownik M, Baum B
  • Publication date:
  • Pagination:
    78, 89
  • Journal:
    Dev Cell
  • Volume:
  • Issue:
  • Country:
    United States
  • PII:
  • Language:
  • Keywords:
    Animals, Animals, Genetically Modified, Body Patterning, Drosophila, Drosophila Proteins, Gene Expression Regulation, Developmental, Genes, Insect, Green Fluorescent Proteins, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Models, Biological, Pseudopodia, Receptors, Notch, Recombinant Proteins, Signal Transduction
The organization of bristles on the Drosophila notum has long served as a popular model of robust tissue patterning. During this process, membrane-tethered Delta activates intracellular Notch signaling in neighboring epithelial cells, which inhibits Delta expression. This induces lateral inhibition, yielding a pattern in which each Delta-expressing mechanosensory organ precursor cell in the epithelium is surrounded on all sides by cells with active Notch signaling. Here, we show that conventional models of Delta-Notch signaling cannot account for bristle spacing or the gradual refinement of this pattern. Instead, the pattern refinement we observe using live imaging is dependent upon dynamic, basal actin-based filopodia and can be quantitatively reproduced by simulations of lateral inhibition incorporating Delta-Notch signaling by transient filopodial contacts between nonneighboring cells. Significantly, the intermittent signaling induced by these filopodial dynamics generates a type of structured noise that is uniquely suited to the generation of well-ordered, tissue-wide epithelial patterns.
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