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Publication Detail
Workshop report on some new ideas about the treatment of systemic lupus erythematosus
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Linnik M, Staines NA, Berden J, Isenberg DA
  • Publication date:
    2002
  • Pagination:
    793, 796
  • Journal:
    Lupus
  • Volume:
    11
  • Issue:
    12
  • Print ISSN:
    0961-2033
  • Keywords:
    anti-CD20, antibodies, Antibody, B CELL, B-cell, benefit, cell, clinical, Clinical trial, Clinical Trials, CLINICAL-TRIAL, CLINICAL-TRIALS, DOUBLE BLIND, DOUBLE-BLIND, experimental, Experimental Model, histone, Idea, IM, LA, Lupus, model, MONOCLONAL ANTIBODIES, MONOCLONAL ANTIBODY, MONOCLONAL-ANTIBODIES, MONOCLONAL-ANTIBODY, PATHOGENESIS, peptide, RATIONALE, report, Result, SYSTEMIC, SYSTEMIC LUPUS ERYTHEMATOSUS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, THERAPIES, therapy, treatment, TRIAL, TRIALS, understanding, Use, work
  • Notes:
    UI - 22416384 DA - 20030116 IS - 0961-2033 LA - eng PT - Journal Article SB - IM
Abstract
Our increased understanding of the pathogenesis of systemic lupus erythematosus is leading to new ideas about its therapy. In this session of the workshop the use of LJP 394 a B cell toleragen and the use of an anti-CD20 monoclonal antibody were discussed in some detail. Their rationale and early clinical results were reviewed; both have shown encouraging clinical and serological benefit. Definitive double-blind clinical trials are still, however, awaited. In addition, the intriguing notion of using a nasal instillation of a histone peptide was described and early work in an experimental model presented
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