UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Molecular genetic pathways in Parkinson's disease: a review.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Jain S, Wood NW, Healy DG
  • Publication date:
    10/2005
  • Pagination:
    355, 364
  • Journal:
    Clin Sci (Lond)
  • Volume:
    109
  • Issue:
    4
  • Status:
    Published
  • Country:
    England
  • Print ISSN:
    0143-5221
  • PII:
    CS20050106
  • Language:
    eng
  • Keywords:
    Chromosome Mapping, Genetic Predisposition to Disease, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Parkinson Disease, Protein-Serine-Threonine Kinases, Ubiquitin-Protein Ligases, alpha-Synuclein
Abstract
Major progress has been made in the last decade in understanding the genetic basis of PD (Parkinson's disease) with five genes unequivocally associated with disease. As a result, multiple pathways have been implicated in the pathogenesis of PD, including proteasome impairment and mitochondrial dysfunction. Although Mendelian genetics has been successful in establishing a genetic predisposition for familial PD, this has not been reiterated in the sporadic form. In fact no genetic factors have been unequivocally associated with increased risk for sporadic PD. The difficulty in identifying susceptibility factors in PD has not only been because of numerous underpowered studies, but we have been unable to dissect out the genetic component in a multifactorial disease. This review aims to summarize the genetic findings within PD.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Clinical and Movement Neurosciences
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by