UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Outcome of a cohort of 300 patients with systemic lupus erythematosus attending a dedicated clinic for over two decades
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Moss KE, Ioannou Y, Sultan SM, Haq I, Isenberg DA
  • Publication date:
    05/2002
  • Pagination:
    409, 413
  • Journal:
    Annals of the Rheumatic Diseases
  • Volume:
    61
  • Issue:
    5
  • Print ISSN:
    0003-4967
  • Keywords:
    adolescent, adult, Age of Onset, Aged, Aged, 80 and over, analysis, As, Cause of Death, Chi-Square Distribution, Child, COHORT, COMMON, DEATH, DEATHS, decade, diagnosis, disease, DURATION, END, Female, FOLLOW, FOLLOW UP, Follow-up, Follow-Up Studies, general population, GENERAL-POPULATION, IM, INCREASED RISK, Infection, Information, Kidney Diseases, LA, Lupus, Lupus Erythematosus, Systemic, Male, MALIGNANCIES, Malignancy, Methods, Middle Age, MORTALITY, outcome, Patient, patients, population, RATES, renal, renal disease, Result, RETROSPECTIVE ANALYSIS, Retrospective Studies, Risk, SLE, SYSTEMIC, SYSTEMIC LUPUS ERYTHEMATOSUS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, UK, vascular, Vascular Disease, VASCULAR-DISEASE
  • Notes:
    UI - 21955968 DA - 20020417 IS - 0003-4967 LA - eng PT - Journal Article SB - IM
Abstract
OBJECTIVE: To examine the mortality rate and causes of death in a cohort of 300 patients with systemic lupus erythematosus (SLE). METHODS: A retrospective analysis was performed on all patients attending the SLE clinic between 1978 and 2000. Information was obtained on those patients lost to follow up. Cause of death was analysed and categorised as early (<5 years after diagnosis of SLE) and late (>5 years after diagnosis of SLE). Standardised mortality rates were obtained. RESULTS: The patients were followed up for a median of 8.3 years. Seventy three (24%) patients were no longer followed up at the end of the study period, of whom 41 (14%) had died. Of the 32 patients lost to follow up, 14 were being actively followed up within the UK, 16 were followed up outside the UK, and two patients were untraceable. The most common cause of death was malignancy, which accounted for eight (20%) deaths, followed by infection and vascular disease, which accounted for seven (17%) deaths each. CONCLUSIONS: Malignancy was the most common cause of death. Cause of death varied depending on disease duration. Forty per cent of early deaths were due to SLE related renal disease, whereas 23% of late deaths were due to vascular causes. Death due to infection occurred throughout the follow up period. There was a fourfold increased risk of death in our cohort of patients with SLE compared with the general population
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Div of Medicine
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by