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Publication Detail
Magnetic Detection of the Sentinel Lymph Node in Ex Vivo Tissue with Colorectal Cancer
  • Publication Type:
    Conference
  • Authors:
    ten Haken B, Visscher M, Pouw JJ, Klaase JM, Pankhurst QA, Galindo-Millan J, Velders AH, Rogalla H
  • Publisher:
    SPRINGER
  • Publication date:
    2010
  • Pagination:
    447, 449
  • Published proceedings:
    17TH INTERNATIONAL CONFERENCE ON BIOMAGNETISM ADVANCES IN BIOMAGNETISM - BIOMAG2010
  • Volume:
    28
  • Editors:
    Supek S,Susac A
  • ISBN-13:
    978-3-642-12196-8
  • Name of conference:
    39th Annual Clinical Aphasiology Conference
  • Conference place:
    Keystone, CO
  • Conference start date:
    26/05/2009
  • Conference finish date:
    30/05/2009
  • Print ISSN:
    1680-0737
  • Language:
    EN
  • Keywords:
    sentinel lymph node, superparamagnetic iron oxides, magnetometry, MRI, BREAST, BIOPSY
  • Addresses:
    ten Haken, B
    Univ Twente
    MIRA Inst Biomed Technol & Tech Med
    Dept Low Temp Biomagnetism
    Enschede
    Netherlands
Abstract
A new method for sentinel lymph node detection was investigated by ex-vivo experiments in colorectal cancer. A dispersion of superparamagnetic iron oxide (SPIO) nanoparticles was injected in the resected tissue around the tumor. A magnetic probe with a 2(nd) order gradiometer configuration was used to localize the sentinel lymph node with accumulated SPIO nanoparticles. Additional analysis of SPIO content was performed on the resected lymph nodes. High-field MRI and conventional microscopy revealed the presence and distribution of SPIO inside the lymph nodes. Magnetometry confirmed SPIO content in lymph nodes and could give an estimate of the amount of SPIO uptake.
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