UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data shown on the profile page to:

http://www.ucl.ac.uk/finance/secure/research/post_award
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Fourier Transform Infrared Spectroscopic Analysis of Breast Cancer Tissues; Identifying Differences between Normal Breast, Invasive Ductal Carcinoma, and Ductal Carcinoma In Situ of the Breast
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Review
  • Authors:
    Rehman S, Movasaghi Z, Darr JA, Rehman IU
  • Publisher:
    TAYLOR & FRANCIS INC
  • Publication date:
    2010
  • Pagination:
    355, 368
  • Journal:
    APPL SPECTROSC REV
  • Volume:
    45
  • Issue:
    5
  • Print ISSN:
    0570-4928
  • PII:
    921286734
  • Language:
    EN
  • Keywords:
    FTIR-ATR spectroscopy, breast carcinoma, invasive ductal carcinoma (IDC), ductal carcinoma in situ (DCIS), breast cancer, RAMAN-SPECTROSCOPY, FTIR SPECTROSCOPY, BIOLOGICAL TISSUES, PROGNOSTIC FACTORS, LUNG TISSUES, SPECTRA, MICROSPECTROSCOPY, CELLS, CLASSIFICATION, EPIDEMIOLOGY
  • Addresses:
    Rehman, IU
    Queen Mary Univ London
    Interdisciplinary Res Ctr Biomed Mat
    London
    E1 4NS
    England
Abstract
A nondestructive method employing Fourier transform infrared (FTIR) microspectroscopy coupled with attenuated total reflectance (ATR) objective for the analysis of histopathological specimens is described. Malignant breast tissue specimens have been analyzed to demonstrate the hypothesis that chemical changes taking place in biological tissue can be reliably and reproducibly identified. This study is the first report to elucidate clear spectral differences between different ductal carcinoma in situ (DCIS) grades. Sixty individual cases of breast carcinoma including DCIS and invasive ductal carcinoma (IDC) and seven cases of normal breast tissues were studied using the FTIR-ATR spectroscopic technique. FTIR analysis of tissue sections has provided distinct spectra that can be used to distinguish between the nuclear grades of DCIS and IDC of the breast. It was concluded that FTIR could objectively and reproducibly discriminate between DCIS and IDC grades without sample destruction. In the future, applications of FTIR approaches should become feasible in the nondestructive express classification of grades and diagnosis of breast carcinoma.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Authors
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by