UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
Autoimmune thyroid disease in systemic lupus erythematosus
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Article
  • Authors:
    Pyne D, Isenberg DA
  • Publication date:
    01/2002
  • Pagination:
    70, 72
  • Journal:
    Annals of the Rheumatic Diseases
  • Volume:
    61
  • Issue:
    1
  • Print ISSN:
    0003-4967
  • Keywords:
    adult, analysis, antibodies, Antibody, Autoantibodies, autoimmune, COHORT, complications, Condition, difference, disease, epidemiology, Female, FREQUENCIES, FREQUENCY, Great Britain, HIGH-FREQUENCY, Hyperthyroidism, Hypothyroidism, IM, Immunoenzyme Techniques, immunology, LA, Lupus, Lupus Erythematosus, Systemic, Middle Age, Note, Patient, patients, population, Prevalence, report, Reports, Result, RETROSPECTIVE ANALYSIS, Retrospective Studies, SHORT-TERM, SLE, small, SYSTEMIC, SYSTEMIC LUPUS ERYTHEMATOSUS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, TERM, Thyroglobulin, thyroid, Thyroid Gland
  • Notes:
    UI - 21637904 DA - 20020107 IS - 0003-4967 LA - eng PT - Journal Article RN - 0 (Autoantibodies) RN - 9010-34-8 (Thyroglobulin) SB - IM
Abstract
BACKGROUND: The reported prevalence of autoimmune thyroid disease (3.9-24%) and antithyroid antibodies (11-51%) in SLE varies considerably. Early reports were mainly based on short term studies of small cohorts. OBJECTIVE: To report the prevalence of autoimmune thyroid disease and thyroid antibodies in 300 patients with SLE, followed up at our centre between 1978 and 2000, by a retrospective analysis of case notes. RESULTS: The prevalence (5.7%) of hypothyroidism in our cohort was higher than in the normal population (1%), while that of hyperthyroidism (1.7%) was not significantly different. Overall 42/300 (14%) of our cohort had thyroid antibodies, rising to 15/22 (68%) in the subgroup who also had thyroid disease (p<0.001). Both antimicrosomal and antithyroglobulin antibodies were detected. The antibodies were found in equally high frequency in the hyperthyroid subgroup (80% patients), whereas in the hypothyroid subgroup antimicrosomal antibodies were more frequent than antithyroglobulin antibodies (64% v 41%). There was no significant difference in the frequency with which antimicrosomal or antithyroglobulin antibodies were detected between the hyperthyroid and hypothyroid subgroups (p>0.2). CONCLUSION: Our patients with SLE had a prevalence of hypothyroidism, but not hyperthyroidism, greater than that of the normal population. The presence of either condition was associated with a higher frequency of both antimicrosomal and antithyroglobulin antibodies
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by