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Publication Detail
Autoimmune thyroid disease in systemic lupus erythematosus
  • Publication Type:
    Journal article
  • Publication Sub Type:
  • Authors:
    Pyne D, Isenberg DA
  • Publication date:
  • Pagination:
    70, 72
  • Journal:
    Annals of the Rheumatic Diseases
  • Volume:
  • Issue:
  • Print ISSN:
  • Keywords:
    adult, analysis, antibodies, Antibody, Autoantibodies, autoimmune, COHORT, complications, Condition, difference, disease, epidemiology, Female, FREQUENCIES, FREQUENCY, Great Britain, HIGH-FREQUENCY, Hyperthyroidism, Hypothyroidism, IM, Immunoenzyme Techniques, immunology, LA, Lupus, Lupus Erythematosus, Systemic, Middle Age, Note, Patient, patients, population, Prevalence, report, Reports, Result, RETROSPECTIVE ANALYSIS, Retrospective Studies, SHORT-TERM, SLE, small, SYSTEMIC, SYSTEMIC LUPUS ERYTHEMATOSUS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, TERM, Thyroglobulin, thyroid, Thyroid Gland
  • Notes:
    UI - 21637904 DA - 20020107 IS - 0003-4967 LA - eng PT - Journal Article RN - 0 (Autoantibodies) RN - 9010-34-8 (Thyroglobulin) SB - IM
BACKGROUND: The reported prevalence of autoimmune thyroid disease (3.9-24%) and antithyroid antibodies (11-51%) in SLE varies considerably. Early reports were mainly based on short term studies of small cohorts. OBJECTIVE: To report the prevalence of autoimmune thyroid disease and thyroid antibodies in 300 patients with SLE, followed up at our centre between 1978 and 2000, by a retrospective analysis of case notes. RESULTS: The prevalence (5.7%) of hypothyroidism in our cohort was higher than in the normal population (1%), while that of hyperthyroidism (1.7%) was not significantly different. Overall 42/300 (14%) of our cohort had thyroid antibodies, rising to 15/22 (68%) in the subgroup who also had thyroid disease (p<0.001). Both antimicrosomal and antithyroglobulin antibodies were detected. The antibodies were found in equally high frequency in the hyperthyroid subgroup (80% patients), whereas in the hypothyroid subgroup antimicrosomal antibodies were more frequent than antithyroglobulin antibodies (64% v 41%). There was no significant difference in the frequency with which antimicrosomal or antithyroglobulin antibodies were detected between the hyperthyroid and hypothyroid subgroups (p>0.2). CONCLUSION: Our patients with SLE had a prevalence of hypothyroidism, but not hyperthyroidism, greater than that of the normal population. The presence of either condition was associated with a higher frequency of both antimicrosomal and antithyroglobulin antibodies
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