UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
PONM09 Thymectomy: its role in the management of myasthenia gravis.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Spillane J, Kullmann DM, Taylor C, Hirsch NP, Howard R
  • Publication date:
    11/2010
  • Pagination:
    e62, e63
  • Journal:
    J Neurol Neurosurg Psychiatry
  • Volume:
    81
  • Issue:
    11
  • Country:
    England
  • Print ISSN:
    1468-330X
  • PII:
    81/11/e62-d
  • Language:
    eng
  • Addresses:
    j.spillane@ion.ucl.ac.uk.
Abstract
Background The role of thymectomy in the management of MG continues to be debated. In the absence of an adequate RCT, it is essential to review clinical experience. Aim To perform a 10 year audit of cases of thymectomy for MG in a tertiary referral centre. Methods Medical case notes of all patients who underwent thymectomy were retrospectively reviewed. Results 79 patients were identified. 22 were male. Average age at thymectomy was 32.5. Indications for thymectomy included: persistence of generalised symptoms (62%), bulbar symptoms (6%), a combination of both (8%), ocular MG (9%) and thymoma (15%). Over 90% were AChR ab positive. 45% had an enlarged gland on mediastinal imaging. Average length of ICU postoperatively was 2.2 days. Immediate postthymectomy complications included pneumonia (3.7%), pneumothorax (3.7%) and wound infection (2.5%); 7.5% suffered a hypertrophic scar. There were no long-term complications. Thymic histology revealed hyperplasia (47%), thymoma (22%), atrophic changes (10%) and a normal gland (21%). 77% of patients achieved an improvement in one point or more on the MGFA scale postthymectomy during follow-up (6 months-2 years). Conclusion Thymectomy is commonly performed for MG and is associated with a sustained improvement in the majority of our patients.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Clinical & Experimental Epilepsy
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by