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Publication Detail
Tuberculosis and anti-TNF treatment: experience of a central London hospital.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Mankia S, Peters JE, Kang S, Moore S, Ehrenstein MR
  • Publication date:
    03/2011
  • Pagination:
    399, 401
  • Journal:
    Clin Rheumatol
  • Volume:
    30
  • Issue:
    3
  • Status:
    Published
  • Country:
    Germany
  • Language:
    eng
  • Keywords:
    Antirheumatic Agents, Etanercept, Humans, Immunoglobulin G, Latent Tuberculosis, London, Receptors, Tumor Necrosis Factor, Tuberculosis
Abstract
Reactivation of latent tuberculosis (TB) is an established risk of anti-tumour necrosis factor α (anti-TNF) therapy. We report five cases of active TB occurring in 703 patients treated with anti-TNF therapy over a 10-year period in a central London hospital and review our screening practices for identifying latent TB prior to anti-TNF treatment. Four patients were receiving adalimumab and one patient etanercept at the time of TB diagnosis. Four of the five patients were born in countries with a high TB prevalence. Two of the five patients were healthcare workers. All patients had normal chest radiographs prior to anti-TNF treatment. Our data emphasise that country of origin is important in the determining risk of latent TB and that a normal chest radiograph does not exclude latent TB.
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