UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
The effect of light on the spread of signals through the rod network of the salamander retina.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Attwell D, Wilson M, Wu SM
  • Publication date:
    16/09/1985
  • Pagination:
    79, 88
  • Journal:
    Brain Res
  • Volume:
    343
  • Issue:
    1
  • Status:
    Published
  • Country:
    Netherlands
  • Print ISSN:
    0006-8993
  • PII:
    0006-8993(85)91160-6
  • Language:
    eng
  • Keywords:
    Ambystoma, Ambystoma mexicanum, Animals, In Vitro Techniques, Light, Membrane Potentials, Photoreceptor Cells, Synaptic Transmission, Vision, Ocular
Abstract
Adjacent rods in the amphibian retina are electrically coupled to each other by gap junctions. By injecting current pulses into one rod and recording the voltage change produced in nearby rods, we have studied the extent to which signals spread between rods in the presence and absence of illumination. Light has little effect on the steady potentials produced in nearby rods by the injection of a hyperpolarizing current, but does affect the propagation of transient signals through the rod network. The responses to injection of depolarizing current are increased by light. These effects of light were mimicked by hyperpolarizing the rod network (non-uniformly) by injecting continuous current (on top of which current pulses were superimposed to monitor signal spread). This suggests that the effects of light are due solely to the rod hyperpolarization produced by light. The effects of light are not completely predicted from computer simulations based on a previous characterization of the properties of isolated rods; these experiments thus reveal an inadequacy in the description of the rod membrane currents in that model. Light-induced hyperpolarization of cones has no effect on signal spread between rods. The functional significance of these results is discussed.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Neuro, Physiology & Pharmacology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by