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Publication Detail
The timing of channel opening during miniature end-plate currents.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Cohen I, van der Kloot W, Attwell D
  • Publication date:
  • Pagination:
    185, 189
  • Journal:
    Brain Res
  • Volume:
  • Issue:
  • Status:
  • Country:
  • Print ISSN:
  • PII:
  • Language:
  • Keywords:
    Acetylcholine, Animals, Kinetics, Mathematics, Membrane Potentials, Motor Endplate, Neuromuscular Junction, Rana pipiens, Receptors, Cholinergic
Many chemical transmitters act by opening channels with exponentially distributed life-times. We present a way to analyze a synaptic current in terms of its component channels. We can estimate the numbers and times of channel opening within the synaptic current. This approach is used to study miniature end-plate currents (m.e.p.c.s) at the frog neuromuscular junction. The results support the idea that some transmitter rebinds after dissociation from post-synaptic receptors, and suggest that the time of channel closing is related to the time at which acetylcholine leaves the receptor.
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