UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
Publication Detail
The dependence on heart rate of the human ventricular action potential duration.
  • Publication Type:
    Journal article
  • Publication Sub Type:
    Journal Article
  • Authors:
    Arnold L, Page J, Attwell D, Cannell M, Eisner DA
  • Publication date:
    10/1982
  • Pagination:
    547, 551
  • Journal:
    Cardiovasc Res
  • Volume:
    16
  • Issue:
    10
  • Status:
    Published
  • Country:
    England
  • Print ISSN:
    0008-6363
  • Language:
    eng
  • Keywords:
    Action Potentials, Adult, Electrocardiography, Female, Heart, Heart Conduction System, Heart Rate, Humans, Male, Physical Exertion, Respiration, Time Factors, Ventricular Function
Abstract
For the human electrocardiogram, the relationship between QT interval and heart rate was examined in conditions where the heart rate was changed at different rates. The QT interval provides a measure of the ventricular action potential duration. For slow changes of heart rate, elicited by mild exercise, the dependence of QT interval on heart rate obtained when the heart rate was rising was the same as that obtained when the heart rate was falling. The QT interval was approximately proportional to 1/(heart rate)1/2. For the rapid transient changes of heart rate associated with respiration, the QT interval was approximately constant, independent of the instantaneous heart rate. For rapid sustained changes of heart rate, elicited by heavy exercise or immersion of the face in cold water, the changes in QT interval lagged behind the heart rate changes. Consequently the dependence of QT interval on heart rate obtained when the heart rate was increasing differed from the dependence obtained during a fall in heart rate. This time dependence of the relationship between QT interval and heart rate is similar to that seen for the relationship between action potential duration and stimulation rate in isolated pieces of mammalian ventricle.
Publication data is maintained in RPS. Visit https://rps.ucl.ac.uk
 More search options
UCL Researchers
Author
Neuro, Physiology & Pharmacology
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by